Diffuse Intrinsic Pontine Glioma : Clinical Features, Molecular Genetics, and Novel Targeted Therapeutics
Journal of Korean Neurosurgical Society
;
: 343-351, 2018.
Article
in English
| WPRIM
| ID: wpr-765257
ABSTRACT
Diffuse intrinsic pontine glioma (DIPG) is a deadly paediatric brain cancer. Transient response to radiation, ineffective chemotherapeutic agents and aggressive biology result in rapid progression of symptoms and a dismal prognosis. Increased availability of tumour tissue has enabled the identification of histone gene aberrations, genetic driver mutations and methylation changes, which have resulted in molecular and phenotypic subgrouping. However, many of the underlying mechanisms of DIPG oncogenesis remain unexplained. It is hoped that more representative in vitro and preclinical models–using both xenografted material and genetically engineered mice–will enable the development of novel chemotherapeutic agents and strategies for targeted drug delivery. This review provides a clinical overview of DIPG, the barriers to progress in developing effective treatment, updates on drug development and preclinical models, and an introduction to new technologies aimed at enhancing drug delivery.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
Biology
/
In Vitro Techniques
/
Brain Neoplasms
/
Histones
/
Brain Stem Neoplasms
/
Heterografts
/
Carcinogenesis
/
Hope
/
Glioma
Type of study:
Prognostic study
Language:
English
Journal:
Journal of Korean Neurosurgical Society
Year:
2018
Type:
Article
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