Intracranial Germ Cell Tumor in the Molecular Era
Journal of Korean Neurosurgical Society
;
: 333-342, 2018.
Article
in English
| WPRIM
| ID: wpr-765258
ABSTRACT
Intracranial germ cell tumors (iGCTs) are a heterogeneous group of tumors with peculiar characteristics clearly distinguished from other brain tumors of neuroepithelial origin. Diverse histology, similarity to gonadal GCT, predilection to one sex, and geographic difference in incidence all present enigmas and fascinating challenges. The treatment of iGCT has advanced for germinoma to date; thus, clinical attention has shifted from survival to long-term quality of life. However, for non-germinomatous GCT, current protocols provide only modest improvement and more innovative therapies are needed. Recently, next-generation sequencing studies have revealed the genomic landscape of iGCT. Novel mutations in the KIT-RAS-MAPK and AKT-MTOR pathways were identified. More importantly, methylation profiling revealed a new method to assess the pathogenesis of iGCT. Molecular research will unleash new knowledge on the origin of iGCT and solve the many mysteries that have lingered on this peculiar neoplasm for a long time.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Quality of Life
/
Brain Neoplasms
/
Incidence
/
Germinoma
/
Neoplasms, Germ Cell and Embryonal
/
Therapies, Investigational
/
Germ Cells
/
Gonads
/
Methods
/
Methylation
Type of study:
Practice guideline
/
Incidence study
/
Prognostic study
Language:
English
Journal:
Journal of Korean Neurosurgical Society
Year:
2018
Type:
Article
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