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Esophageal Motor Dysfunctions in Gastroesophageal Reflux Disease and Therapeutic Perspectives
Journal of Neurogastroenterology and Motility ; : 499-507, 2019.
Article in English | WPRIM | ID: wpr-765975
ABSTRACT
Gastroesophageal reflux disease (GERD) is a very common disease, and the prevalence in the general population has recently increased. GERD is a chronic relapsing disease associated with motility disorders of the upper gastrointestinal tract. Several factors are implicated in GERD, including hypotensive lower esophageal sphincter, frequent transient lower esophageal sphincter relaxation, esophageal hypersensitivity, reduced resistance of the esophageal mucosa against the refluxed contents, ineffective esophageal motility, abnormal bolus transport, deficits initiating secondary peristalsis, abnormal response to multiple rapid swallowing, and hiatal hernia. One or more of these mechanisms result in the reflux of stomach contents into the esophagus, delayed clearance of the refluxate, and the development of symptoms and/or complications. New techniques, such as 24-hour pH and multichannel intraluminal impedance monitoring, multichannel intraluminal impedance and esophageal manometry, high-resolution manometry, 3-dimensional high-resolution manometry, enoscopic functional luminal imaging probe, and 24-hour dynamic esophageal manometry, provide more information on esophageal motility and have clarified the pathophysiology of GERD. Proton pump inhibitors remain the preferred pharmaceutical option to treat GERD. The ideal target of GERD treatment is to restore esophageal motility and reconstruct the anti-reflux mechanism. This review focuses on current advances in esophageal motor dysfunction in patients with GERD and the influence of these developments on GERD treatment.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Peristalsis / Phenobarbital / Relaxation / Pharmaceutical Preparations / Esophageal Motility Disorders / Gastroesophageal Reflux / Prevalence / Electric Impedance / Deglutition / Upper Gastrointestinal Tract Type of study: Prevalence study Limits: Humans Language: English Journal: Journal of Neurogastroenterology and Motility Year: 2019 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Peristalsis / Phenobarbital / Relaxation / Pharmaceutical Preparations / Esophageal Motility Disorders / Gastroesophageal Reflux / Prevalence / Electric Impedance / Deglutition / Upper Gastrointestinal Tract Type of study: Prevalence study Limits: Humans Language: English Journal: Journal of Neurogastroenterology and Motility Year: 2019 Type: Article