Association between Expression of 8-OHdG and Cigarette Smoking in Non-small Cell Lung Cancer
Journal of Pathology and Translational Medicine
;
: 217-224, 2019.
Article
in English
| WPRIM
| ID: wpr-766030
ABSTRACT
BACKGROUND:
Exposure to cigarette smoking (CS) is a major risk factor for the development of lung cancer. CS is known to cause oxidative DNA damage and mutation of tumor-related genes, and these factors are involved in carcinogenesis. 8-Hydroxydeoxyguanosine (8-OHdG) is considered to be a reliable biomarker for oxidative DNA damage. Increased levels of 8-OHdG are associated with a number of pathological conditions, including cancer. There are no reports on the expression of 8-OHdG by immunohistochemistry in non-small cell lung cancer (NSCLC).METHODS:
We investigated the expression of 8-OHdG and p53 in 203 NSCLC tissues using immunohistochemistry and correlated it with clinicopathological features including smoking.RESULTS:
The expression of 8-OHdG was observed in 83.3% of NSCLC. It was significantly correlated with a low T category, negative lymph node status, never-smoker, and longer overall survival (p < .05) by univariate analysis. But multivariate analysis revealed that 8-OHdG was not an independent prognostic factor for overall survival in NSCLC patients. The aberrant expression of p53 significantly correlated with smoking, male, squamous cell carcinoma, and Ki-67 positivity (p < .05).CONCLUSIONS:
The expression of 8-OHdG was associated with good prognostic factors. It was positively correlated with never-smokers in NSCLC, suggesting that oxidative damage of DNA cannot be explained by smoking alone and may depend on complex control mechanisms.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Smoke
/
DNA Damage
/
DNA
/
Immunohistochemistry
/
Carcinoma, Squamous Cell
/
Smoking
/
Multivariate Analysis
/
Risk Factors
/
Carcinoma, Non-Small-Cell Lung
/
Tobacco Products
Type of study:
Etiology study
/
Prognostic study
/
Risk factors
Limits:
Humans
/
Male
Language:
English
Journal:
Journal of Pathology and Translational Medicine
Year:
2019
Type:
Article
Similar
MEDLINE
...
LILACS
LIS