AMP kinase/cyclooxygenase-2 pathway regulates proliferation and apoptosis of cancer cells treated with quercetin
Experimental & Molecular Medicine
;
: 201-207, 2009.
Article
in English
| WPRIM
| ID: wpr-76610
ABSTRACT
AMPK (AMP-activated protein kinase) is highly conserved in eukaryotes, where it functions primarily as a sensor of cellular energy status. Recent studies indicate that AMPK activation strongly suppresses cell proliferation in non-malignant cells as well as in tumor cells. In this study, quercetin activated AMPK in MCF breast cancer cell lines and HT-29 colon cancer cells, and this activation of AMPK seemed to be closely related to a decrease in COX-2 expression. The application of a COX-2 inhibitor or cox-2(-/-) cells supported the idea that AMPK is an upstream signal of COX-2, and is required for the anti-proliferatory and pro-apoptotic effects of quercetin. The suppressive or growth inhibitory effects of quercetin on COX-2 were abolished by treating cancer cells with an AMPK inhibitor Compound C. These results suggest that AMPK is crucial to the anti-cancer effect of quercetin and that the AMPK-COX-2 signaling pathway is important in quercetin-mediated cancer control.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pyrazoles
/
Pyrimidines
/
Quercetin
/
Cell Cycle
/
Anticarcinogenic Agents
/
Apoptosis
/
Cell Line, Tumor
/
Cell Proliferation
/
Enzyme Activation
/
Cyclooxygenase 2
Limits:
Humans
Language:
English
Journal:
Experimental & Molecular Medicine
Year:
2009
Type:
Article
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