Interrelationship of Uric Acid, Gout, and Metabolic Syndrome: Focus on Hypertension, Cardiovascular Disease, and Insulin Resistance
Journal of Rheumatic Diseases
;
: 19-27, 2018.
Article
in English
| WPRIM
| ID: wpr-766164
ABSTRACT
The mean serum uric acid level and the prevalence of hyperuricemia have increased over the past few decades. Hyperuricemia is considered to be responsible for the increased risk of hypertension, insulin resistance, and cardiovascular disease. Metabolic syndrome also contributes to the development of type II diabetes mellitus and cardiovascular disease. Despite the close relationships between uric acid and the components of metabolic syndrome, the causal effect of uric acid on these clinical issues is unclear. Recent studies have revealed the possible development of metabolic syndrome mediated by fructose-induced hyperuricemia. This review summarizes the available clinical and experimental data supporting the causal effect of uric acid on the components of metabolic syndrome, including hypertension, cardiovascular disease, and insulin resistance.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Uric Acid
/
Insulin Resistance
/
Cardiovascular Diseases
/
Prevalence
/
Hyperuricemia
/
Diabetes Mellitus
/
Gout
/
Hypertension
/
Insulin
Type of study:
Prevalence study
Language:
English
Journal:
Journal of Rheumatic Diseases
Year:
2018
Type:
Article
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