Etiology and treatment of central precocious puberty
Journal of the Korean Medical Association
;
: 591-598, 2018.
Article
in Korean
| WPRIM
| ID: wpr-766456
ABSTRACT
The timing of pubertal onset is occurring at younger ages. This phenomenon is associated with many environmental factors such as sufficient nutrition, stress, many kinds of endocrine-disrupting chemicals, and genetic background. The loss of transcriptional repression induces kisspeptin release, resulting in pulsatile gonadotropin-releasing hormone secretion, which trigger pubertal onset. According to many reports, gonadotropin-releasing hormone agonists therapy for patients with rapidly progressive central precocious puberty is effective for improving final adult height. However, those results were obtained from the treatment of relatively young patients at earlier stages of puberty. A large cohort study investigating the environmental causes of precocious puberty as well as genetic factors is needed.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Puberty, Precocious
/
Repression, Psychology
/
Cohort Studies
/
Gonadotropin-Releasing Hormone
/
Puberty
/
Endocrine Disruptors
/
Genetic Background
Type of study:
Etiology study
/
Incidence study
/
Observational study
/
Risk factors
Limits:
Adolescent
/
Adult
/
Humans
Language:
Korean
Journal:
Journal of the Korean Medical Association
Year:
2018
Type:
Article
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