Genetic Polymorphisms in VIR Genes among Indian Plasmodium vivax Populations
The Korean Journal of Parasitology
;
: 557-564, 2014.
Article
in English
| WPRIM
| ID: wpr-76771
ABSTRACT
The vir genes are antigenic genes and are considered to be possible vaccine targets. Since India is highly endemic to Plasmodium vivax, we sequenced 5 different vir genes and investigated DNA sequence variations in 93 single-clonal P. vivax isolates. High variability was observed in all the 5 vir genes; the vir 1/9 gene was highly diverged across Indian populations. The patterns of genetic diversity do not follow geographical locations, as geographically distant populations were found to be genetically similar. The results in general present complex genetic diversity patterns in India, requiring further in-depth population genetic and functional studies.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Phylogeny
/
Plasmodium vivax
/
Polymorphism, Genetic
/
Protozoan Proteins
/
Malaria, Vivax
/
India
/
Antigens, Protozoan
Limits:
Humans
Country/Region as subject:
Asia
Language:
English
Journal:
The Korean Journal of Parasitology
Year:
2014
Type:
Article
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