Prognostic Significance of High Expression of ER-beta in Surgically Treated ER-Positive Breast Cancer Following Endocrine Therapy / 한국유방암학회지
Journal of Breast Cancer
;
: 79-86, 2012.
Article
in English
| WPRIM
| ID: wpr-77078
ABSTRACT
PURPOSE:
This study evaluated estrogen receptor (ER)-beta mRNA and ER-beta protein expression and its prognostic implications in hormone receptor-positive breast cancer.METHODS:
Paraffin sections from 139 hormone receptor-positive breast cancer cases were prepared. The expression of ER-beta mRNA and protein were analyzed by branched-chain assay and immunohistochemistry (IHC), respectively.RESULTS:
The Allred score of ER-beta IHC was correlated with smaller tumor size (p=0.043), the Allred score of ER-alpha IHC (p<0.001), and the Allred score of progesterone receptor (PR) IHC (p=0.022) but not with the HER2 IHC score. ER-beta mRNA level was correlated with PR mRNA levels (p<0.001) but not with the Allred score of ER-beta IHC, ER-alpha IHC, and PR IHC, nor with the HER2 IHC score and ER-alpha mRNA level. In survival analysis, high expression of ER-beta mRNA was associated with worse disease-free survival along with poor differentiation, lymph node metastasis and absence of PR protein expression in univariate analysis (p=0.040, p=0.002, p=0.018, and p=0.007, respectively) and multivariate analysis (p=0.044, p=0.002, p=0.035, and p=0.007, respectively).CONCLUSION:
High expression of ER-beta mRNA is an independent predictor of disease recurrence in hormone-receptor-positive breast cancer.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Paraffin
/
Prognosis
/
Recurrence
/
Breast
/
Breast Neoplasms
/
RNA, Messenger
/
Immunohistochemistry
/
Receptors, Progesterone
/
Multivariate Analysis
/
Disease-Free Survival
Type of study:
Prognostic study
Language:
English
Journal:
Journal of Breast Cancer
Year:
2012
Type:
Article
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