The effect of low-and high-dose adjunctive mitomycin C in trabeculectomy
Korean Journal of Ophthalmology
;
: 42-47, 1996.
Article
in English
| WPRIM
| ID: wpr-77086
ABSTRACT
To compare the effects of three different concentrations of mitomycin C (MMC) as an adjunct therapy to trabeculectomy, we reviewed 26 patients (36 eyes) who underwent trabeculectomy in which MMC was applied intraoperatively. The time of application was 5 minutes, and the concentration of MMC was 0.1 mg/ml (n = 10), 0.2 mg/ml (n = 17) and 0.4 mg/ml (n = 9), respectively. Complete success was defined by intraocular pressure (IOP) of 21 mmHg or less without medication at postoperative 3 months. There was no statistical difference among the three groups in mean age of patients, preoperative IOPs, and the numbers of premedication. The mean IOP at postoperative 3 months was significantly lower in the 0.4 mg/ml group (10.4 +/- 5.5 mmHg) than in the 0.2 mg/ml group (16.1 +/- 4.7 mmHg) (p 0.05). There was no statistical difference among the three groups in the success rate regardless of medication, and the size and longevity of the filtering bleb. Postoperative hypotony was noted in two eyes of the 0.4 mg/ml group.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Ophthalmic Solutions
/
Postoperative Complications
/
Trabeculectomy
/
Glaucoma
/
Retrospective Studies
/
Follow-Up Studies
/
Mitomycin
/
Chemotherapy, Adjuvant
/
Dose-Response Relationship, Drug
/
Intraocular Pressure
Type of study:
Observational study
/
Prognostic study
Limits:
Adolescent
/
Adult
/
Aged
/
Child
/
Humans
Language:
English
Journal:
Korean Journal of Ophthalmology
Year:
1996
Type:
Article
Similar
MEDLINE
...
LILACS
LIS