The Relationship Between Serum Total Bilirubin and Framingham Risk Score in Healthy Korean Men
Korean Journal of Health Promotion
;
: 1-7, 2013.
Article
in English
| WPRIM
| ID: wpr-771028
ABSTRACT
BACKGROUND:
Serum total bilirubin has been considered a harmful substance inducing oxidative reaction; but recently, there have been reports of it possessing antioxidative, anti-inflammatory and protective features against cardiovascular diseases. The purpose of this study was to investigate the relationship between total bilirubin and the Framingham risk score.METHODS:
This study involved 3,414 healthy Korean men who underwent a medical check-up in a health promotion center in 2008. We calculated the Framingham risk score using age, smoking status, systolic blood pressure, total cholesterol and high-density lipoprotein cholesterol.RESULTS:
The mean age of the participants was 44.9+/-8.8 years. The log transformed serum total bilirubin level and the Framingham risk score had a negative linear relationship in a simple linear regression analysis (R2 0.018, P<0.001). In a multivariable analysis model, as well, the log transformed serum total bilirubin level and the Framingham risk score had a negative linear relationship (R2 0.384, P<0.001).CONCLUSIONS:
Our study showed a statistically significant negative relationship between total bilirubin and the Framingham risk score. Total bilirubin had a stronger relationship with the Framingham risk score than other standard cardiovascular risk factors except smoking, and thus may be useful in predicting cardiovascular risk in the outpatient clinic.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Smoke
/
Bilirubin
/
Blood Pressure
/
Cardiovascular Diseases
/
Smoking
/
Linear Models
/
Cholesterol
/
Risk Factors
/
Ambulatory Care Facilities
/
Health Promotion
Type of study:
Etiology study
/
Prognostic study
/
Risk factors
Limits:
Humans
/
Male
Language:
English
Journal:
Korean Journal of Health Promotion
Year:
2013
Type:
Article
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