Type 2 diabetes is causally associated with depression: a Mendelian randomization analysis / 医学前沿
Frontiers of Medicine
;
(4): 678-687, 2018.
Article
in English
| WPRIM
| ID: wpr-771273
ABSTRACT
Type 2 diabetes (T2D) has been associated with a high prevalence of depression.We aimed to determine the causal relation by performing a Mendelian randomization (MR) study using 34 T2D risk genetic variants validated in East Asians as the instrumental variable (IV). An MR analysis was performed involving 11 506 participants from a large longitudinal study. The T2D genetic risk score (GRS) was built using the 34 typical T2D common variants. We used T2D_GRS as the IV estimator and performed inverse-variance weighted (IVW) and Egger MR analysis. The T2D_GRS was found to be associated with depression with an OR of 1.21 (95% CI 1.07-1.37) after adjustments for age, sex, body mass index, current smoking and drinking, physical activity, education, and marital status. Using T2D_GRS as the IV, we similarly found a causal relationship between genetically determined T2D and depression (OR 1.84, 95% CI 1.25-2.70). Though we found no association between the combined effect of the genetic IVs for T2D and depression with EggerMR(OR 0.95, 95%CI 0.42-2.14), we found an association for T2D and depression with IVW (OR 1.75, 95% CI 1.31-2.46) after excluding pleiotropic SNPs. Overall, the MR analyses provide evidence inferring a potential causal relationship between T2D and depression.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Psychiatric Status Rating Scales
/
Psychology
/
Genetic Variation
/
Linear Models
/
China
/
Epidemiology
/
Causality
/
Risk Factors
/
Longitudinal Studies
/
Sensitivity and Specificity
Type of study:
Controlled clinical trial
/
Diagnostic study
/
Etiology study
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Aged
/
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
English
Journal:
Frontiers of Medicine
Year:
2018
Type:
Article
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