Your browser doesn't support javascript.
loading
Mesenchymal stem cells and immune disorders: from basic science to clinical transition / 医学前沿
Frontiers of Medicine ; (4): 138-151, 2019.
Article in English | WPRIM | ID: wpr-771295
ABSTRACT
As a promising candidate seed cell type in regenerative medicine, mesenchymal stem cells (MSCs) have attracted considerable attention. The unique capacity of MSCs to exert a regulatory effect on immunity in an autologous/allergenic manner makes them an attractive therapeutic cell type for immune disorders. In this review, we discussed the current knowledge of and advances in MSCs, including its basic biological properties, i.e., multilineage differentiation, secretome, and immunomodulation. Specifically, on the basis of our previous work, we proposed three new concepts of MSCs, i.e., "subtotipotent stem cell" hypothesis, MSC system, and "Yin and Yang" balance of MSC regulation, which may bring new insights into our understanding of MSCs. Furthermore, we analyzed data from the Clinical Trials database ( http//clinicaltrials.gov ) on registered clinical trials using MSCs to treat a variety of immune diseases, such as graft-versus-host disease, systemic lupus erythematosus, and multiple sclerosis. In addition, we highlighted MSC clinical trials in China and discussed the challenges and future directions in the field of MSC clinical application.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Physiology / Randomized Controlled Trials as Topic / Cell Differentiation / Mesenchymal Stem Cell Transplantation / Regenerative Medicine / Allergy and Immunology / Mesenchymal Stem Cells / Immune System Diseases Type of study: Controlled clinical trial Limits: Humans Language: English Journal: Frontiers of Medicine Year: 2019 Type: Article

Similar

MEDLINE

...
LILACS

LIS

Full text: Available Index: WPRIM (Western Pacific) Main subject: Physiology / Randomized Controlled Trials as Topic / Cell Differentiation / Mesenchymal Stem Cell Transplantation / Regenerative Medicine / Allergy and Immunology / Mesenchymal Stem Cells / Immune System Diseases Type of study: Controlled clinical trial Limits: Humans Language: English Journal: Frontiers of Medicine Year: 2019 Type: Article