Deubiquitinases as pivotal regulators of T cell functions / 医学前沿
Frontiers of Medicine
;
(4): 451-462, 2018.
Article
in English
| WPRIM
| ID: wpr-771296
ABSTRACT
T cells efficiently respond to foreign antigens to mediate immune responses against infections but are tolerant to self-tissues. Defect in T cell activation is associated with severe immune deficiencies, whereas aberrant T cell activation contributes to the pathogenesis of diverse autoimmune and inflammatory diseases. An emerging mechanism that regulates T cell activation and tolerance is ubiquitination, a reversible process of protein modification that is counter-regulated by ubiquitinating enzymes and deubiquitinases (DUBs). DUBs are isopeptidases that cleave polyubiquitin chains and remove ubiquitin from target proteins, thereby controlling the magnitude and duration of ubiquitin signaling. It is now well recognized that DUBs are crucial regulators of T cell responses and serve as potential therapeutic targets for manipulating immune responses in the treatment of immunological disorders and cancer. This review will discuss the recent progresses regarding the functions of DUBs in T cells.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Physiology
/
T-Lymphocytes
/
Signal Transduction
/
Cell Differentiation
/
Drug Therapy
/
Ubiquitination
/
Drug Discovery
/
Deubiquitinating Enzymes
/
Metabolism
Limits:
Humans
Language:
English
Journal:
Frontiers of Medicine
Year:
2018
Type:
Article
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