Challenges of NK cell-based immunotherapy in the new era / 医学前沿
Frontiers of Medicine
;
(4): 440-450, 2018.
Article
in English
| WPRIM
| ID: wpr-771299
ABSTRACT
Natural killer cells (NKs) have a great potential for cancer immunotherapy because they can rapidly and directly kill transformed cells in the absence of antigen presensitization. Various cellular sources, including peripheral blood mononuclear cells (PBMCs), stem cells, and NK cell lines, have been used for producing NK cells. In particular, NK cells that expanded from allogeneic PBMCs exhibit better efficacy than those that did not. However, considering the safety, activities, and reliability of the cell products, researchers must develop an optimal protocol for producing NK cells from PBMCs in the manufacture setting and clinical therapeutic regimen. In this review, the challenges on NK cell-based therapeutic approaches and clinical outcomes are discussed.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Therapeutics
/
Killer Cells, Natural
/
Treatment Outcome
/
Allergy and Immunology
/
Immunotherapy
/
Methods
/
Neoplasms
Type of study:
Practice guideline
Limits:
Humans
Language:
English
Journal:
Frontiers of Medicine
Year:
2018
Type:
Article
Similar
MEDLINE
...
LILACS
LIS