Progress in epigenetic modification of mRNA and the function of m6A modification / 生物工程学报
Chinese Journal of Biotechnology
;
(12): 775-783, 2019.
Article
in Chinese
| WPRIM
| ID: wpr-771332
ABSTRACT
Messenger RNA (mRNA) can be modified by more than 100 chemical modifications. Among these modifications, N6-methyladenosine (m⁶A) is one of the most prevalent modifications. During the processes of cells differentiation, embryo development or stress, m⁶A can be modified on key mRNAs and regulate the progress of cells through modulating mRNA metabolism and translation. Other mRNA modifications, including N1-methyladenosine (m¹A), 5-methylcytosine (m⁵C) and pseudouridine, together with m⁶A form the epitranscriptome of mRNA that accurately modulate the mRNA translation. Here we review the types and characteristic of mRNA epigenetic modifications, especially the recent progresses of the function of m⁶A, we also expect the main research direction of m⁶A epigenetic modification in the future.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
RNA, Messenger
/
Cell Differentiation
/
Adenosine
/
RNA Processing, Post-Transcriptional
/
Gene Expression Regulation
/
Epigenesis, Genetic
/
Embryonic Development
/
Genetics
/
Metabolism
Language:
Chinese
Journal:
Chinese Journal of Biotechnology
Year:
2019
Type:
Article
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