Advances in antibody drug expression techniques / 生物工程学报
Chinese Journal of Biotechnology
;
(12): 171-182, 2019.
Article
in Chinese
| WPRIM
| ID: wpr-771389
ABSTRACT
The 21st century is regarded as the century of biotechnological drugs, among which monoclonal antibodies and their derived targeting drugs have established themselves as the leading modality of biopharmaceutical pharmaceutics for a wide range of indications covering malignant tumors and autoimmune disorders. Since the manufacturing of the first antibody drug from hybridoma cells, the technologies have been intensely studied and there emerged numerous breakthroughs in recombinant cell line establishment, antibody expression and purification, quality control and other related areas. This article summarizes the critical progresses of antibody drugs expression technologies, especially of mammalian cell expression system, Escherichia coli expression system, the transgenic animal reactor and the cell free protein synthesis system, to give a detailed illustration of the recent advances in antibody drugs development.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Biotechnology
/
Cell Line
/
Escherichia coli
/
Hybridomas
/
Antibodies, Monoclonal
Limits:
Animals
Language:
Chinese
Journal:
Chinese Journal of Biotechnology
Year:
2019
Type:
Article
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