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Characterization of overall biopharmaceutical properties of traditional Chinese medicine components based on identification of representational components / 中国中药杂志
China Journal of Chinese Materia Medica ; (24): 4592-4598, 2018.
Article in Chinese | WPRIM | ID: wpr-771544
ABSTRACT
Preformulation research, an in-depth research for pharmacological and pharmaceutical properties of raw materials, has been widely used in the field of chemical drugs. Although traditional Chinese medicine components (TCMCs) are the basic units in Chinese medicine preparation, the properties characterization of these components is still in an exploratory stage, because empiricism and blindness are still present in the development of the Chinese medicine preparations. TCMCs, a complex multi-component system, is very difficult to be analyzed in details. Herein, a research idea is put forward for the characterization of overall properties by using representative compositions. Firstly, various composition groups were set up for screening the representative components by in vitro and in vivo efficacy evaluation according to the original proportion. Then the equilibrium solubility, oil/water (O/W) partition coefficient and apparent permeability coefficient of the representative components were detected. Subsequently, the similarity assessment and discrete analysis were performed for the subdivision of TCMCs. The overall properties of TCMCs were fitted by mass fraction or efficacy contribution of each representative component, so as to characterize the overall properties of components/sub-components.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Solubility / Drugs, Chinese Herbal / Medicine, Chinese Traditional Type of study: Diagnostic study Language: Chinese Journal: China Journal of Chinese Materia Medica Year: 2018 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Solubility / Drugs, Chinese Herbal / Medicine, Chinese Traditional Type of study: Diagnostic study Language: Chinese Journal: China Journal of Chinese Materia Medica Year: 2018 Type: Article