A new isoflavone derivative from Rosa Damascena and its antibacterial activity / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 332-335, 2018.
Article
in Chinese
| WPRIM
| ID: wpr-771733
ABSTRACT
A new isoflavone derivative was isolated from Rosa damascena by using various chromatographic techniques including silica gel, Sephadex LH-20, and preparative RP-HPLC separation. Its structure was identified as 4'-hydroxy-7-(3-hydroxypropanoyl)-6-methoxy-isoflavone using combined examinations of their UV, IR, MS, and NMR spectroscopic data. Biological activity test showed that this compound showed prominent antibacterial activity with MIC₉₀ value of (46±4) mg·L⁻¹ for methicillin resistant Staphylococcus aureus(MRSA) strain. This value is close to that of levofloxacin [with MIC₉₀ value (53±5) mg·L⁻¹].
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Microbial Sensitivity Tests
/
Chemistry
/
Rosa
/
Methicillin-Resistant Staphylococcus aureus
/
Phytochemicals
/
Isoflavones
/
Anti-Bacterial Agents
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2018
Type:
Article
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