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Genomics approaches decode natural products synthesis / 生物工程学报
Chinese Journal of Biotechnology ; (12): 1889-1900, 2019.
Article in Chinese | WPRIM | ID: wpr-771745
ABSTRACT
Novel natural products have always been the most important sources for discovery of new drugs. Since the end of the 20th century, advances in genomics technology have contributed to decode and analyze numerous genomes, revealing remarkable potential for production of new natural products in organisms. However, this potential is hampered by laboratory culture conditions. Therefore, the integration of all these new advances is necessary to unveil these treasures, addressing the rise in resistance to antibiotics. In this review, we discuss the strategies of genome mining, inducing the expression of silent biosynthetic gene clusters and construction of biological chassis.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Biological Products / Multigene Family / Genome / Genomics / Biosynthetic Pathways / Genetics / Metabolism Limits: Animals Language: Chinese Journal: Chinese Journal of Biotechnology Year: 2019 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Biological Products / Multigene Family / Genome / Genomics / Biosynthetic Pathways / Genetics / Metabolism Limits: Animals Language: Chinese Journal: Chinese Journal of Biotechnology Year: 2019 Type: Article