Correlation of Epstein-Barr Virus Infection with Prognosis of Children with Acute B Lymphoblastic Leukemia / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 769-776, 2019.
Article
in Chinese
| WPRIM
| ID: wpr-771886
ABSTRACT
OBJECTIVE@#To explore the correlation of EB virus infection with the prognosis of B-ALL children.@*METHODS@#The peripheral blood of children with newly diagnosed B-ALL admitted in Children's Hospital of Chongqing Medical University from January 2012 to December 2017 were collected, and the EBV DNA in plasma was detected by real-time quantitative PCR. The clinical data of B-ALL children were collected and the correlation of EBV infection with the prognosis of B-ALL children was analyzed.@*RESULTS@#Among 162 B-ALL children, the EBV infection rate was 41.36%. Univariate analysis showed that the B-ALL children with EBV infection had the poor prognosis and higher risk of shorter survival time, as compared with B-ALL children without EBV infection (HR=2.373, 95% CI 1.129-4.987) (P<0.05), the multivariate analysis showed that the result was consistent with result of univariate analysis indicating that EBV infection was an independent predictor for poor prognosis of B-ALL children.@*CONCLUSION@#The EBV infection may play an important role in the occurrence and progression of B-ALL and is an independent predictor for poor prognosis, therefore the detection of EBV DNA in plasma of B-ALL children possesses an important significance for evaluation of B-ALL children's prognosis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
DNA, Viral
/
B-Lymphocytes
/
Herpesvirus 4, Human
/
Epstein-Barr Virus Infections
/
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Type of study:
Prognostic study
Limits:
Child
/
Humans
Language:
Chinese
Journal:
Journal of Experimental Hematology
Year:
2019
Type:
Article
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