Risk factors analysis of gestational diabetes mellitus based on International Association of Diabetes Pregnancy Study Groups criteria / 南方医科大学学报

ABSTRACT

OBJECTIVE@#To study the risk factors for gestational diabetes mellitus (GDM).@*METHODS@#This retrospective case-control study was conducted among women registered at the Department of Obstetrics of West China Second University Hospital between March, 2016 and May, 2018. The women were divided into case group (GDM) and control group (Non- GDM) according to the diagnosis of GDM based on the International Association of Diabetes Pregnancy Study Groups (IADPSG) criteria. The data including age, education level, ethnicity and other socio-demographic data, as well as the gestational week, parity, polycystic ovary syndrome, family history of diabetes, fat mass, total body water, minerals and other clinical characteristics were collected. Univariate Logistic regression analysis was performed and the variables with statistical difference and clinical significance were included in multivariate Logistic regression analysis to identify the risk factors of GDM.@*RESULTS@#A total of 3608 pregnant women were included in the study. Univariate logistic analysis revealed that age, previous GDM, intracellular/extracellular water, fat mass, arm circumference, skeletal muscle mass were risk factors for GDM. Multivariate logistic analysis showed that age, previous GDM, family history of DM, and an arm circumference ≥28.5 cm were independent risk factors for GDM after controlling pre-pregnancy BMI. The risk of GDM in pregnant women aged 30-35 years and 36 years or older was 1.883 ( < 0.001) and 2.883 ( < 0.001) times of that in women aged 20-29 years, respectively. Women with a history of GDM had a 6.604 ( < 0.001) greater risk of developing GDM than women without a history of GDM. Compared with those without a family history of diabetes, those with a family history of diabetes were 2.518 times more likely to develop GDM ( < 0.001). Compared with those with an arm circumference no greater than 25.5 cm, pregnant women with an arm circumference over 28.5 cm had an increased risk of GDM by 2.815 times ( < 0.001). High fat free mass was a protective factor for GDM, and compared with a fat free mass below 35.1 kg, a fat free mass over 40.1 kg was associated with a lowered risk of GDM by 0.515 times ( < 0.001).@*CONCLUSIONS@#The onset of GDM was affected by multiple factors. Age, history of GDM, family history of diabetes, and a large arm circumference are all independent risk factors of GDM and should be controlled to reduce the incidence of GDM.