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Effect of glucagon-like peptide 1 receptor agonists on body fat redistribution and muscle mass in overweight and obese type 2 diabetic patients / 南方医科大学学报
Journal of Southern Medical University ; (12): 450-455, 2019.
Article in Chinese | WPRIM | ID: wpr-772080
ABSTRACT
OBJECTIVE@#To investigate the effect of glucagon-like peptide 1 receptor agonists (GLP-1RAs) on body fat redistribution and muscle mass in overweight/obese patients with type 2 diabetes (T2DM).@*METHODS@#We retrospectively analyzed the data of 76 patients with body mass indexes (BMI)≥24 kg/m, who had an established diagnosis of T2DM in our department between December, 2014 and September, 2015. We divided these patients according to their BMI in overweight group (BMI of 24-27.9 kg/m, =14), obese group (BMI of 28-31.9 kg/m, =35) and severely obese group (BMI≥32 kg/m, =27). All the patients received treatment with GLP-1RAs (Exenatide or Liraglutide) for 3.0 to 29.0 weeks (mean 8.9 weeks), and their blood glucose, HbA1c and serum lipids were analyzed. For each patient, the fat and muscle masses were analyzed using a human body composition analyzer (JAWON-IOI353, Korea) before and after GLP-1RAs treatment.@*RESULTS@#Treatment with GLP-1RAs significantly decreased BMI and visceral adiposity index (VAI) in all the patients in the 3 groups ( < 0.05). The treatment significantly decreased the body weight in the overweight group and obese group by 2.70 kg (0.60-4.95 kg) and 2.65 kg (1.45-6.40 kg), respectively ( < 0.05), and significantly decreased the waist-to-hip ratio (WHR) in the overweight group ( < 0.05). The obese and severely obese patients showed significantly decreased percentage body fat (including both subcutaneous and visceral fat) and increased muscle mass after the treatment ( < 0.05). Compared with those in the overweight group, the percentage body fat and VAI were significantly decreased in the obese group after the treatment ( < 0.05), and the percentage of subcutaneous fat reduced and the muscle ratio increased more obviously in the obese and severely obese patients ( < 0.05).@*CONCLUSIONS@#GLP-1RAs treatment can significantly lower BMI and improve body fat distribution in obese patients with T2DM, especially in patients with a greater BMI.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Body Mass Index / Adipose Tissue / Retrospective Studies / Diabetes Mellitus, Type 2 / Overweight / Glucagon-Like Peptide-1 Receptor / Hypoglycemic Agents / Obesity Type of study: Observational study Limits: Humans Language: Chinese Journal: Journal of Southern Medical University Year: 2019 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Body Mass Index / Adipose Tissue / Retrospective Studies / Diabetes Mellitus, Type 2 / Overweight / Glucagon-Like Peptide-1 Receptor / Hypoglycemic Agents / Obesity Type of study: Observational study Limits: Humans Language: Chinese Journal: Journal of Southern Medical University Year: 2019 Type: Article