Progress in the research of negative feedback effect of thyroglobulin / 南方医科大学学报
Journal of Southern Medical University
;
(12): 125-126, 2019.
Article
in Chinese
| WPRIM
| ID: wpr-772110
ABSTRACT
Thyroglobulin is the most important and abundant protein in thyroid follicles and has been widely studied as a tumor marker of thyroid cancer recurrence and persistence. Tg is considered the material basis of thyroid hormone synthesis and does not participate in the regulation of thyroid hormone synthesis and secretion. This review summarizes the recent progress in the research of thyroid hormone synthesis and secretion regulation via a negative feedback regulation mechanism by the thyroid-hypothalamus-pituitary axis. Thyroglobulin can negatively regulate the synthesis of thyroid hormone by thyroid follicular cells and antagonize the positive regulation of thyrotropin TSH. The function of thyroid follicular cells is presumably a result of Tg and TSH interaction, and a follicular cycle model is proposed to explain the causes of follicular heterogeneity in glands. We also discuss the prospects and clinical significance of studies into the negative feedback regulation mechanism of the thyroid-hypothalamus-pituitary axis and compare two theories for this mechanism.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Physiology
/
Thyroglobulin
/
Thyroid Gland
/
Thyroid Hormones
/
Thyrotropin
/
Feedback, Physiological
/
Hypothalamo-Hypophyseal System
/
Metabolism
/
Neoplasm Recurrence, Local
Limits:
Humans
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2019
Type:
Article
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