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Clinical Evaluation of A New Pathological Classification for 
Non-small Cell Lung Cancer Based on Histogenesis of Bronchial Tree / 中国肺癌杂志
Chinese Journal of Lung Cancer ; (12): 530-535, 2018.
Article in Chinese | WPRIM | ID: wpr-772406
ABSTRACT
BACKGROUND@#Due in part to remarkable advances over the past decade in our understanding of lung cancer, there is a pressing need for a revised classification. The aim of this study was to explore and verify the clinical significance of a new molecular classification of non-small cell lung cancer (NSCLC) on the basis of anatomic site of bronchial tree.@*METHODS@#Double-immunohistochemistry were performed in 105 tumor samples paring with normal lung tissue from non-small cell lung cancer patients by using monoclonal antibody of P63/NapsinA and TTF-1/CK7. By comprehensively analyzing the express profiles of tumors and normal lung tissues, histological characteristics we proposed a brand new pathological classification based on histogenesis for NSCLC and divided them as bronchiole epithelial cell carcinoma, bronchiole-alveolar cell carcinoma, alveolar cell carcinoma and secretory adenocarcinoma. And to analyze the relationship between this classification and epidermal growth factor receptor (EGFR) mutation and ognosis.@*RESULTS@#Further investigation revealed that our new classification showed strong relevancy with EGFR mutations and effective indicators for prognosis.@*CONCLUSIONS@#The classification system for NSCLC proposed by our research group is convenient for pathological diagnosis and valuable in clinical application.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Bronchi / Classification / Carcinoma, Non-Small-Cell Lung / Lung Neoplasms Type of study: Prognostic study Limits: Aged / Female / Humans / Male Language: Chinese Journal: Chinese Journal of Lung Cancer Year: 2018 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Bronchi / Classification / Carcinoma, Non-Small-Cell Lung / Lung Neoplasms Type of study: Prognostic study Limits: Aged / Female / Humans / Male Language: Chinese Journal: Chinese Journal of Lung Cancer Year: 2018 Type: Article