A Case Report of Advanced Lung Adenocarcinoma Harboring KRAS Mutation
Treated with Anlotinib / 中国肺癌杂志
Chinese Journal of Lung Cancer
;
(12): 428-430, 2018.
Article
in Chinese
| WPRIM
| ID: wpr-772422
ABSTRACT
In recent years, the number of advanced non-small cell lung cancer (NSCLC) patients has gradually increased, and the treatment methods have also been significantly increased. However, there are no standard treatment plans at home and abroad for third-line and above patients who are refractory to targeted therapy epidermal growth factor receptor (EGFR)/anaplastic lymphoma kinase (ALK) or chemotherapy. The clinical treatment effect is also not satisfactory. Anlotinib is a novel TKI targeting the vascular endothelial growth factor receptor (VEGFR), fibroblast growth factor receptor (FGFR), platelet-derived growth factor receptor (PDGFR) and c-Kit. ALTER0303 trail, phase III study has demonstrated that Anlotinib significantly prolonged overall survival (OS) and progression-free survival (PFS) in advanced NSCLC patients as 3rd line treatment.Here we report a case of advanced lung adenocarcinoma harboring KRAS mutation treated with Anlotinib.
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Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Quinolines
/
Adenocarcinoma
/
Proto-Oncogene Proteins p21(ras)
/
Therapeutic Uses
/
Drug Therapy
/
Adenocarcinoma of Lung
/
Genetics
/
Indoles
/
Lung Neoplasms
Limits:
Aged
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Lung Cancer
Year:
2018
Type:
Article
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