Genome editing for the treatment of tumorigenic viral infections and virus-related carcinomas / 医学前沿
Frontiers of Medicine
;
(4): 497-508, 2018.
Article
in English
| WPRIM
| ID: wpr-772710
ABSTRACT
Viral infections cause at least 10%-15% of all human carcinomas. Over the last century, the elucidation of viral oncogenic roles in many cancer types has provided fundamental knowledge on carcinogenetic mechanisms and established a basis for the early intervention of virus-related cancers. Meanwhile, rapidly evolving genome-editing techniques targeting viral DNA/RNA have emerged as novel therapeutic strategies for treating virus-related carcinogenesis and have begun showing promising results. This review discusses the recent advances of genome-editing tools for treating tumorigenic viruses and their corresponding cancers, the challenges that must be overcome before clinically applying such genome-editing technologies, and more importantly, the potential solutions to these challenges.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Antiviral Agents
/
Therapeutics
/
Tumor Virus Infections
/
Virology
/
Carcinoma
/
Genetic Therapy
/
Genetic Predisposition to Disease
/
Therapeutic Uses
/
CRISPR-Cas Systems
/
Gene Editing
Limits:
Humans
Language:
English
Journal:
Frontiers of Medicine
Year:
2018
Type:
Article
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