Effects of Lidocaine and Propofol on Production of Interleukin (IL)-2, IL-4, and Nitric Oxide in Mice / 대한마취과학회지
Korean Journal of Anesthesiology
;
: 671-678, 2005.
Article
in Korean
| WPRIM
| ID: wpr-77298
ABSTRACT
BACKGROUND:
The possibility that anesthesia may alter the course of an infection has been under consideration for more a century. Alterations have been found in every component of the immune response during anesthesia and surgery. In this work, we have investigated the effect of lidocaine and propofol on interleukin-2 (IL-2), interleukin-4 (IL-4), and nitric oxide (NO) production in mice.METHODS:
The culture supernatants of splenocytes exposed with anesthetics and lipopolysaccharide (LPS), or sera from mice injected with these agents were harvested to assay IL-2, IL-4, and NO.RESULTS:
We detected that IL-2 productions of splenocytes culture supernatants and mice sera after exposure with lidocaine or propofol were decreased while IL-4 productions were increased. In addition, NO of mice sera was increased after lidocaine or propofol exposures.CONCLUSIONS:
These findings suggest that lidocaine and propofol interfere with IL-2, IL-4, and NO production. This may explain the clinically well-recognized disturbance of human immunity after surgery and anesthesia.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Propofol
/
Interleukins
/
Interleukin-4
/
Interleukin-2
/
Anesthesia
/
Anesthetics
/
Lidocaine
/
Nitric Oxide
Limits:
Animals
/
Humans
Language:
Korean
Journal:
Korean Journal of Anesthesiology
Year:
2005
Type:
Article
Similar
MEDLINE
...
LILACS
LIS