Structural Insights into N-methyladenosine (mA) Modification in the Transcriptome / 基因组蛋白质组与生物信息学报·英文版
Genomics, Proteomics & Bioinformatics
;
(4): 85-98, 2018.
Article
in English
| WPRIM
| ID: wpr-772999
ABSTRACT
More than 100 types of chemical modifications in RNA have been well documented. Recently, several modifications, such as N-methyladenosine (mA), have been detected in mRNA, opening the window into the realm of epitranscriptomics. The mA modification is the most abundant modification in mRNA and non-coding RNA (ncRNA). At the molecular level, mA affects almost all aspects of mRNA metabolism, including splicing, translation, and stability, as well as microRNA (miRNA) maturation, playing essential roles in a range of cellular processes. The mA modification is regulated by three classes of proteins generally referred to as the "writer" (adenosine methyltransferase), "eraser" (mA demethylating enzyme), and "reader" (mA-binding protein). The mA modification is reversibly installed and removed by writers and erasers, respectively. Readers, which are members of the YT521-B homology (YTH) family proteins, selectively bind to RNA and affect its fate in an mA-dependent manner. In this review, we summarize the structures of the functional proteins that modulate the mA modification, and provide our insights into the mA-mediated gene regulation.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
RNA, Messenger
/
Adenosine
/
Chemistry
/
Gene Expression Regulation
/
RNA-Binding Proteins
/
RNA, Untranslated
/
Transcriptome
/
Metabolism
/
Methyltransferases
Limits:
Animals
/
Humans
Language:
English
Journal:
Genomics, Proteomics & Bioinformatics
Year:
2018
Type:
Article
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