Your browser doesn't support javascript.
loading
Genetic polymorphisms of autophagy-related gene 5 (ATG5) rs473543 predict different disease-free survivals of triple-negative breast cancer patients receiving anthracycline- and/or taxane-based adjuvant chemotherapy / 癌症
Chinese Journal of Cancer ; (12): 4-4, 2018.
Article in English | WPRIM | ID: wpr-773009
ABSTRACT
BACKGROUND@#Autophagy plays a crucial role in chemotherapy resistance of triple-negative breast cancer (TNBC). Hence, autophagy-related gene 5 (ATG5), an essential molecule involved in autophagy regulation, is presumably associated with recurrence of TNBC. This study was aimed to investigate the potential influence of single-nucleotide polymorphisms in ATG5 on the disease-free survival (DFS) of early-stage TNBC patients treated with anthracycline- and/or taxane-based chemotherapy.@*METHODS@#We genotyped ATG5 SNP rs473543 in a cohort of 316 TNBC patients treated with anthracycline- and/or taxane-based chemotherapy using the sequenom's MassARRAY system. Kaplan-Meier survival analysis and Cox proportional hazard regression analysis were used to analyze the association between ATG5 rs473543 genotypes and the clinical outcome of TNBC patients.@*RESULTS@#Three genotypes, AA, GA, and GG, were detected in the rs473543 of ATG5 gene. The distribution of ATG5 rs473543 genotypes was significantly different between patients with and without recurrence (P = 0.024). Kaplan-Meier survival analysis showed that patients carrying A allele of ATG5 rs473543 had an increased risk of recurrence and shorter DFS compared with those carrying the variant genotype GG in rs473543 (P = 0.034). In addition, after adjusting for clinical factors, multivariate Cox regression analyses revealed that the AA/GA genotype of rs473543 was an independent predictor for DFS (hazard risk [HR], 1.73; 95% confidence interval [CI], 1.04-2.87; P = 0.034). In addition, DFS was shorter in node-negative patients with the presence of A allele (AA/GA) than in those with the absence of A allele (P = 0.027).@*CONCLUSION@#ATG5 rs473543 genotypes may serve as a potential marker for predicting recurrence of early-stage TNBC patients who received anthracycline-and/or taxane-based regimens as adjuvant chemotherapy.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Bridged-Ring Compounds / Chemotherapy, Adjuvant / Disease-Free Survival / Anthracyclines / Genetic Predisposition to Disease / Polymorphism, Single Nucleotide / Taxoids / Drug Therapy / Kaplan-Meier Estimate Type of study: Prognostic study Limits: Adult / Aged / Female / Humans Language: English Journal: Chinese Journal of Cancer Year: 2018 Type: Article

Similar

MEDLINE

...
LILACS

LIS

Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Bridged-Ring Compounds / Chemotherapy, Adjuvant / Disease-Free Survival / Anthracyclines / Genetic Predisposition to Disease / Polymorphism, Single Nucleotide / Taxoids / Drug Therapy / Kaplan-Meier Estimate Type of study: Prognostic study Limits: Adult / Aged / Female / Humans Language: English Journal: Chinese Journal of Cancer Year: 2018 Type: Article