Application of CD19-CAR T Cells in Refractory Relapsed Acute B Lymphocyte Leukemia / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 1604-1609, 2018.
Article
in Chinese
| WPRIM
| ID: wpr-773049
ABSTRACT
OBJECTIVE@#To investigate the efficacy of CD19-targeted chimeric antigen receptor T-cell (CD19-CAR T) in the treatment of patients with refractory relapsed B cell acute lymphocyte leukemia(B-ALL).@*METHODS@#The efficacy and safety of CD19-CAR T cells in treatment of patients with refractory relapsed B-ALL from January 2015 to July 2017 in the Department of Hematology of Peking University Third Hospital were analyzed retrospectively.@*RESULTS@#A total of 10 patients were included in this analysis, all of which were consistent with the diagnosis of refractory relapsed B-ALL, and the immunophenotype of leukemia cells was CD19 positive. After treatment with CD19-CAR T cells, the overall response rate(ORR) on day 28 was 70%. Among them, 6 cases reached complete remission(CR), 1 case reached partial remission(PR). The rate of CR on day 90 was 30%.@*CONCLUSION@#CD19-CAR T cells are effective in the treatment of refractory relapsed B-ALL, and the adverse reactions are controllable.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Recurrence
/
B-Lymphocytes
/
Receptors, Antigen, T-Cell
/
T-Lymphocytes
/
Leukemia, B-Cell
/
Acute Disease
/
Retrospective Studies
/
Immunotherapy, Adoptive
/
Antigens, CD19
Type of study:
Observational study
Limits:
Humans
Language:
Chinese
Journal:
Journal of Experimental Hematology
Year:
2018
Type:
Article
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