Intestinal absorption of phenolic acids in Rhus chinensis extracts by in situ single-pass perfusion model in rats / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 2373-2378, 2019.
Article
in Chinese
| WPRIM
| ID: wpr-773084
ABSTRACT
The intestinal absorption properties of four main effective components(gallic acid, ocinolglucoside, ethyl gallate and penta-O-galloyl-β-D-glucose) in Rhus chinensis extracts were investigated by in situ single-pass intestinal perfusion model in rats. The liquid accumulation of perfusion was corrected by gravimetry. The HPLC method was established to determine the concentration of the four effective components in the intestinal perfusion. It showed significant differences(Pethyl gallate>gallic acid>ocinolglucoside, with significant differences between them(P<0.05). In conclusion, gallic acid, orpheolglucoside, ethyl gallate and pentacyl-glucose could be absorbed in the whole intestine. Their absorption rate and permeation ability were related to the intestinal section and the perfusate concentration. These results indicated potential active transport or facilitated diffusion in the intestinal transport process of the four effective components.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Perfusion
/
Chemistry
/
Chromatography, High Pressure Liquid
/
Rhus
/
Phytochemicals
/
Hydroxybenzoates
/
Intestinal Absorption
/
Metabolism
Limits:
Animals
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2019
Type:
Article
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