A new polyketide from marine-derived Streptomyces sp.MDW-06 / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 2090-2095, 2019.
Article
in Chinese
| WPRIM
| ID: wpr-773123
ABSTRACT
To isolate and identify secondary metabolites of marine-derived Streptomyces sp.MDW-06,the isolations and purifications of compounds were performed by means of column chromatography over silica gel. And their structures were elucidated through the spectroscopic analysis of MS,NMR and specific rotations. The bioactivities were assayed by paper diffusion and DPPH method. From the fermentation broth of marine-derived Streptomyces sp.MDW-06,five compounds( 1-5) were isolated and identified as streptopentanoic acid( 1),germicidin A( 2),germicidin B( 3),isogermicidin A( 4),isogermicidin B( 5) and oxohygrolidin( 6),respectively. Compound 1 is a new compound. Compound 1 shows DPPH radical scavenging activity with 36. 4% at 100 mg·L~(-1).
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Streptomyces
/
Magnetic Resonance Spectroscopy
/
Chemistry
/
Chromatography
/
Free Radical Scavengers
/
Fermentation
/
Polyketides
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2019
Type:
Article
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