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LC-MS guided isolation of two anti-inflammatory cyclic dihydrochalcane trimers from Chinese dragon's blood / 中国中药杂志
Article in Chinese | WPRIM | ID: wpr-773274
Responsible library: WPRO
ABSTRACT
As an important integral part of traditional Chinese medicine chemical biology( TCMCB),it is of great importance to rapid isolate,and reliably identify the chemical components in herbal medicines. Phytochemical studies on the anti-inflammatory active part of Chinese dragon's blood,the red resin of Dracaena cochinchinensis,resulted in the isolation of two compounds,nordracophane( 1) and dracophane( 2),using LC-MS and chromatographic techniques( Silica gel,ODS and preparative HPLC). The structures,cyclic dihydrochalcane trimers,were elucidated on the basis of 1 D and 2 D NMR,MS,IR and UV spectral analysis. Compound 1 is a new compound,and 2 is isolated from D. cochinchinensis for the first time. Both compounds exhibited significant inhibition of nitric oxide production in lipopolysaccharides( LPS)-stimulated RAW264. 7 cells with IC50 values of( 14. 9±4. 50) and( 9. 0±0. 7) μmol·L-1.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Mass Spectrometry / Plant Extracts / Chromatography, Liquid / Dracaena / Animals / Metabolism / Mice / Anti-Inflammatory Agents / Nitric Oxide Language: Chinese Journal: China Journal of Chinese Materia Medica Year: 2019 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Mass Spectrometry / Plant Extracts / Chromatography, Liquid / Dracaena / Animals / Metabolism / Mice / Anti-Inflammatory Agents / Nitric Oxide Language: Chinese Journal: China Journal of Chinese Materia Medica Year: 2019 Type: Article