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Study on liver protection and hepatotoxicity of saikosaponin a based on zebrafish model / 中国中药杂志
Article in Chinese | WPRIM | ID: wpr-773276
Responsible library: WPRO
ABSTRACT
Bupleuri Radix has both liver protection and hepatotoxicity. Saponins are the main pharmacodynamic and toxic components of Bupleuri Radix. Based on zebrafish physical model and the model of alcoholic fatty liver( AFL) pathology,the liver toxic and protective effect of saikosaponin a( SSa) were assessed. The results indicated that 1. 77 μmol·L-1 SSa showed protective effect to AFL zebrafish. 5. 30 μmol·L-1 SSa was hepatotoxic to healthy zebrafish,but it showed protective effect to AFL zebrafish. 5. 62 μmol·L-1 SSa was hepatotoxic to healthy and AFL zebrafish. This study is benefit for clinical safety of saikosaponin a.
Subject(s)

Full text: Available Index: WPRIM (Western Pacific) Main subject: Oleanolic Acid / Pharmacology / Saponins / Zebrafish / Drug Therapy / Toxicity / Fatty Liver, Alcoholic / Chemical and Drug Induced Liver Injury / Animals Language: Chinese Journal: China Journal of Chinese Materia Medica Year: 2019 Type: Article
Full text: Available Index: WPRIM (Western Pacific) Main subject: Oleanolic Acid / Pharmacology / Saponins / Zebrafish / Drug Therapy / Toxicity / Fatty Liver, Alcoholic / Chemical and Drug Induced Liver Injury / Animals Language: Chinese Journal: China Journal of Chinese Materia Medica Year: 2019 Type: Article