Consensus on the detection of microsatellite instability in colorectal cancer and other related solid tumors in China / 中华肿瘤杂志
Chinese Journal of Oncology
;
(12): 734-741, 2019.
Article
in Chinese
| WPRIM
| ID: wpr-773350
ABSTRACT
Microsatellite instability (MSI) which resulted from the deficiency of DNA mismatch repair (MMR), is an important clinical significance in the related solid tumors, such as colorectal cancer and endometrial cancer. There are several methods to detect MSI status, including immunohistochemistry for MMR protein, multiplex fluorescent polymerase chain reaction (PCR) for microsatellite site and MSI algorithm based on next generation sequencing (NGS). The consensus elaborates the definition and clinical significance of MSI as well as the advantages and disadvantages of the three detection methods. Through this expert consensus, we hope to promote the screening which based on MSI status in malignant tumors and improve the acknowledge of clinicians about various testing methods. Thereby, they could interpret the results more accurately and provide better clinical services to patients.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Reference Standards
/
Immunohistochemistry
/
Colorectal Neoplasms
/
China
/
Polymerase Chain Reaction
/
Endometrial Neoplasms
/
Practice Guidelines as Topic
/
Microsatellite Repeats
/
Delivery of Health Care
Type of study:
Diagnostic study
/
Practice guideline
Limits:
Female
/
Humans
Country/Region as subject:
Asia
Language:
Chinese
Journal:
Chinese Journal of Oncology
Year:
2019
Type:
Article
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