Subchronic Oral Cadmium Exposure Exerts both Stimulatory and Suppressive Effects on Pulmonary Inflammation/Immune Reactivity in Rats / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences
;
(12): 508-519, 2019.
Article
in English
| WPRIM
| ID: wpr-773377
ABSTRACT
OBJECTIVE@#The aim of this study is to investigate the effects of oral cadmium (Cd) ingestion on the pulmonary immune response.@*METHODS@#Determination of Cd content in lungs and histopathological evaluation of the tissue was performed in rats following 30-day oral Cd administration (5 and 50 mg/L). Antioxidant enzyme defense (superoxide dismutase and catalase), cell infiltration, and production of tumor necrosis factor (TNF) and interferon (IFN)-γ, as well as the activity of myeloperoxidase (MPO), nitric oxide (NO), and various cytokines [interleukin (IL)-1β, IL-6, IL-10, and IL-17] were investigated.@*RESULTS@#Cd caused tissue damage and cell infiltration in the lungs, and this damage was more pronounced at higher doses. Cd deposition resulted in lung inflammation characterized by a dose-dependent IL-1β increase in lung homogenates, increased TNF levels at both doses, and IL-6 stimulation at low doses with inhibition observed at higher doses. Cd exerted differential effects on lung leukocytes isolated by enzyme digestion, and these effects were characterized by a lack of change in the production of reactive oxygen and nitrogen species, an inhibition of IL-1β and TNF, and stimulation of MPO and IFN-γ. The higher capacity of Cd-exposed lung cells to respond to the opportunistic pathogen Staphylococcus epidermidis was demonstrated in vitro.@*CONCLUSION@#The potential of ingested Cd to exert both proinflammatory and immunosuppressive effects on pulmonary tissue inflammation and immune reactivity highlights the complex immunomodulatory actions of this metal.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Staphylococcus epidermidis
/
Cadmium
/
Administration, Oral
/
Allergy and Immunology
/
Toxicity
/
Toxicity Tests, Subchronic
/
Leukocytes
/
Lung
/
Metabolism
Limits:
Animals
Language:
English
Journal:
Biomedical and Environmental Sciences
Year:
2019
Type:
Article
Similar
MEDLINE
...
LILACS
LIS