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Computed tomography findings, clinicopathological features, genetic characteristics and prognosis of and minimally invasive lung adenocarcinomas / 南方医科大学学报
Journal of Southern Medical University ; (12): 1107-1112, 2019.
Article in Chinese | WPRIM | ID: wpr-773496
ABSTRACT
OBJECTIVE@#To investigate the computed tomography findings, clinicopathological features, genetic characteristics and prognosis of in situ adenocarcinoma (AIS) and minimally invasive adenocarcinoma (MIA) of the lung.@*METHODS@#We retrospectively analyzed the data including computed tomography (CT) images, histopathological findings, Ki-67 immunostaining, and genetic mutations in patients with lung adenocarcinoma undergoing surgery at our hospital between 2014 and 2019.@*RESULTS@#Of the total of 480 patients with lung adenocarcinoma we reviewed, 73 (15.2%) had AIS (=28) or MIA (=45) tumors. The age of the patients with MIA was significantly younger than that of patients with AIS ( < 0.02). CT scans identified pure ground-glass nodules in 46.4% of AIS cases and in 44.4% of MIA cases. Multiple GGOs were more common in MIA than in AIS cases ( < 0.05), and bluured tumor margins was less frequent in AIS cases ( < 0.05). No significant difference was found in EGFR mutations between MIA and AIS cases. A Ki-67 labeling index (LI) value ≥2.8% did not differentiate MIA from AIS. The follow-up time in MIA group was significantly shorter than that in AIS group, but no recurrence or death occurred.@*CONCLUSIONS@#Despite similar surgical outcomes and favorable survival outcomes, the patients with AIS and MIA show differences in terms of age, CT findings, EGFR mutations and Ki-67 LI.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Prognosis / Diagnostic Imaging / Tomography, X-Ray Computed / Retrospective Studies / Ki-67 Antigen / ErbB Receptors / Adenocarcinoma of Lung / Genetics / Lung Neoplasms Type of study: Diagnostic study / Observational study / Prognostic study Limits: Humans Language: Chinese Journal: Journal of Southern Medical University Year: 2019 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Prognosis / Diagnostic Imaging / Tomography, X-Ray Computed / Retrospective Studies / Ki-67 Antigen / ErbB Receptors / Adenocarcinoma of Lung / Genetics / Lung Neoplasms Type of study: Diagnostic study / Observational study / Prognostic study Limits: Humans Language: Chinese Journal: Journal of Southern Medical University Year: 2019 Type: Article