Correlation between methylation level of and genes and aging in healthy individuals / 南方医科大学学报
Journal of Southern Medical University
;
(12): 724-730, 2019.
Article
in Chinese
| WPRIM
| ID: wpr-773542
ABSTRACT
OBJECTIVE@#To analyze the relationship between and gene methylation with aging in the general population.@*METHODS@#We collected peripheral blood samples from 284 male and 246 female healthy subjects for detection of methylation levels of and genes using quantitative methylation-specific PCR (qMSP). The relationship between the methylation levels of and genes and aging was analyzed using Spearman or Pearson correlation test.@*RESULTS@#We found a significant positive correlation between the methylation levels of the two genes in these subjects ( < 0.05). In the overall population as well in the female subjects, methylation was found to be inversely correlated with age ( < 0.05). The methylation levels of and genes were inversely correlated with TG, ApoE, Lp(a) and AST in the overall population ( < 0.05). In both the female and male subjects, the methylation levels of the two genes were inversely correlated with Lp(a) ( < 0.05). In the male subjects, methylation was inversely correlated with AST ( < 0.05), while methylation was inversely correlated with HDL and ApoE ( < 0.05). In the female subjects, methylation was positively correlated with LDL and inversely correlated with ApoE and AST ( < 0.05).@*CONCLUSIONS@#The methylation levels of and are closely related to age and the levels of multiple proteins in healthy subjects.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Aging
/
DNA Methylation
/
Cyclin-Dependent Kinase Inhibitor p16
/
Cyclin-Dependent Kinase Inhibitor p15
/
Real-Time Polymerase Chain Reaction
/
Metabolism
Limits:
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2019
Type:
Article
Similar
MEDLINE
...
LILACS
LIS