Design, synthesis, and biological evaluation of novel nitric oxide releasing dehydroandrographolide derivatives / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
;
(6): 782-790, 2018.
Article
in English
| WPRIM
| ID: wpr-773561
ABSTRACT
A series of new hybrids of dehydroandrographolide (TAD), a biologically active natural product, bearing nitric oxide (NO)-releasing moieties were synthesized and designated as NO-donor dehydroandrographolide. The biological activities of target compounds were studied in human erythroleukemia K562 cells and breast cancer MCF-7 cells. Biological evaluation indicated that the most active compound I-5 produced high levels of NO and inhibited the proliferation of K562 (IC 1.55 μmol·L) and MCF-7 (IC 2.91 μmol·L) cells, which were more potent than the lead compound TAD and attenuated by an NO scavenger. In conclusion, I-5 is a novel hybrid with potent antitumor activity and may become a promising candidate for future intensive study.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Structure-Activity Relationship
/
Drug Screening Assays, Antitumor
/
Drug Design
/
Chemistry
/
K562 Cells
/
Cell Proliferation
/
Diterpenes
/
MCF-7 Cells
/
Antineoplastic Agents
Limits:
Humans
Language:
English
Journal:
Chinese Journal of Natural Medicines (English Ed.)
Year:
2018
Type:
Article
Similar
MEDLINE
...
LILACS
LIS