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Scopariusols L-T, nine new ent-kaurane diterpenoids isolated from Isodon scoparius / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.) ; (6): 456-464, 2018.
Article in English | WPRIM | ID: wpr-773596
ABSTRACT
Nine new ent-kaurane diterpenoids, named scopariusols L-T (1-9), were isolated from the aerial parts of Isodon scoparius. Their structures were characterized mainly by analyzing the NMR and HR-ESI-MS data, and the absolute configuration of 1 was determined by single-crystal X-ray diffraction. Compound 1 was active against five human tumor cell lines (HL-60, SMMC-7721, A-549, MCF-7, and SW-480), and it also inhibited NO production in LPS-stimulated RAW264.7 cells, with an IC value of 0.6 μmol·L.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pharmacology / Drug Screening Assays, Antitumor / Drugs, Chinese Herbal / Molecular Structure / Chemistry / Lipopolysaccharides / Crystallography, X-Ray / HL-60 Cells / Nuclear Magnetic Resonance, Biomolecular / Isodon Limits: Animals / Humans Language: English Journal: Chinese Journal of Natural Medicines (English Ed.) Year: 2018 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pharmacology / Drug Screening Assays, Antitumor / Drugs, Chinese Herbal / Molecular Structure / Chemistry / Lipopolysaccharides / Crystallography, X-Ray / HL-60 Cells / Nuclear Magnetic Resonance, Biomolecular / Isodon Limits: Animals / Humans Language: English Journal: Chinese Journal of Natural Medicines (English Ed.) Year: 2018 Type: Article