Novel triterpene saponins isolated from Clematis mandshurica and their inhibitory activities on NO production / 中国天然药物
Chinese Journal of Natural Medicines (English Ed.)
;
(6): 131-138, 2018.
Article
in English
| WPRIM
| ID: wpr-773633
ABSTRACT
Four new triterpene saponins, mandshunosides F-I (1-4), together with five known compounds (5-9), were isolated from the roots and rhizomes of Clematis mandshurica. Their structures were elucidated on the basis of spectroscopic evidences and hydrolysis products. Bisdesmosidic saponin (3-9) showed modest suppression of NO production with the inhibition ratios in the range of 51.3%- 64.6% at 50 μmol·L, whereas monodesmosidic saponins with a free carboxyl group at C-28 (1 and 2) showed potent inhibitory activities with IC values being 12.7 and 8.3 μmol·L, respectively.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Saponins
/
Triterpenes
/
Drugs, Chinese Herbal
/
Molecular Structure
/
Chemistry
/
Rhizome
/
Clematis
/
Macrophages
/
Metabolism
Limits:
Animals
Language:
English
Journal:
Chinese Journal of Natural Medicines (English Ed.)
Year:
2018
Type:
Article
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