Changes of some biochemical markers and cardiac function in New Zealand rabbits with chronic heart failure / 中国应用生理学杂志
Chinese Journal of Applied Physiology
;
(6): 74-77, 2018.
Article
in Chinese
| WPRIM
| ID: wpr-773799
ABSTRACT
OBJECTIVE@#This article investigated the changes of some biochemical markers and cardiac function in chronic heart failure (CHF), and provided the basis for the diagnosis of CHF.@*METHODS@#New Zealand rabbit CHF model was established using adriamycin (ADR). Twenty New Zealand rabbits were randomly divided into model group (=15) and control group (=5), injected with ADR and saline solution the ear vein respectively, 2 times a week, lasting for 8 weeks. After that, myocardial enzymes, carotid artery pressure, echocardiogram (ECG) and phonocardiogram (PCG) of all New Zealand rabbits were detected and recorded.@*RESULTS@#Compared with control group, all parameters of the model group were changed significantly (<0.05).@*CONCLUSIONS@#CHF leads to myocardial damage in New Zealand rabbits, decreased systolic and diastolic function, cardiac reserve index can be used to assess cardiac function.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Phonocardiography
/
Blood Pressure
/
Biomarkers
/
Carotid Arteries
/
Doxorubicin
/
Random Allocation
/
Chronic Disease
/
Electrocardiography
/
Heart Failure
/
Myocardium
Limits:
Animals
Language:
Chinese
Journal:
Chinese Journal of Applied Physiology
Year:
2018
Type:
Article
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