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Clinical effect and safety of different maintenance doses of caffeine citrate in treatment of apnea in very low birth weight preterm infants: a prospective randomized controlled trial / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics ; (12): 558-561, 2019.
Article in Chinese | WPRIM | ID: wpr-774034
ABSTRACT
OBJECTIVE@#To study the clinical effect and safety of different maintenance doses of caffeine citrate in the treatment of apnea in very low birth weight preterm infants.@*METHODS@#A total of 78 very low birth weight preterm infants with primary apnea were enrolled who were admitted from January 2016 to January 2018. They were randomly divided into high-dose caffeine group with 38 children and low-dose caffeine group with 40 children. Both groups received a loading dose of 20 mg/kg caffeine citrate, and 24 hours later, the children in the high-dose caffeine group were given a maintenance dose of 10 mg/kg, and those in the low-dose caffeine group were given a maintenance dose of 5 mg/kg. The two groups were compared in terms of response rate and incidence rate of adverse events.@*RESULTS@#The high-dose caffeine group had a significantly higher response rate than the low-dose caffeine group (71% vs 48%; P0.05). There was no significant difference in the mortality rate between the two groups (P>0.05).@*CONCLUSIONS@#Higher maintenance dose of caffeine citrate has a better clinical effect than lower maintenance dose of caffeine citrate in the treatment of apnea in very low birth weight preterm infants, without increasing the incidence rates of adverse drug reactions and serious complications in preterm infants.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Apnea / Caffeine / Infant, Premature / Prospective Studies / Citrates / Infant, Very Low Birth Weight / Therapeutic Uses / Drug Therapy Type of study: Controlled clinical trial / Observational study / Risk factors Limits: Child / Humans / Infant / Infant, Newborn Language: Chinese Journal: Chinese Journal of Contemporary Pediatrics Year: 2019 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Apnea / Caffeine / Infant, Premature / Prospective Studies / Citrates / Infant, Very Low Birth Weight / Therapeutic Uses / Drug Therapy Type of study: Controlled clinical trial / Observational study / Risk factors Limits: Child / Humans / Infant / Infant, Newborn Language: Chinese Journal: Chinese Journal of Contemporary Pediatrics Year: 2019 Type: Article