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Significance of NUDT15 gene in individualized treatment with 6-mercaptopurine in children with acute lymphoblastic leukemia / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics ; (12): 100-104, 2019.
Article in Chinese | WPRIM | ID: wpr-774120
ABSTRACT
As an important drug during maintenance treatment of acute lymphoblastic leukemia (ALL), 6-mercaptopurine (6-MP) has several side effects, including hepatotoxicity and bone marrow suppression. Since its tolerability varies from person to person, 6-MP treatment should be individualized. The deficiency of thiopurine methyltransferase (TPMT) enzyme activity is associated with 6-MP intolerance. There is a lower frequency of mutation in TPMT alleles among Asian patients. Recent studies have shown that in ALL patients with NUDT15 gene mutation, the maximum tolerated dose of 6-MP is lower than the conventional dose. The article reviews the significance of NUDT15 gene in individualized treatment with 6-MP in children with ALL.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Pyrophosphatases / Precursor Cell Lymphoblastic Leukemia-Lymphoma / Genetics / Mercaptopurine / Methyltransferases / Antimetabolites, Antineoplastic Limits: Child / Humans Language: Chinese Journal: Chinese Journal of Contemporary Pediatrics Year: 2019 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pyrophosphatases / Precursor Cell Lymphoblastic Leukemia-Lymphoma / Genetics / Mercaptopurine / Methyltransferases / Antimetabolites, Antineoplastic Limits: Child / Humans Language: Chinese Journal: Chinese Journal of Contemporary Pediatrics Year: 2019 Type: Article