Regulation of tumor cell glycometabolism and tumor therapy / 生物医学工程学杂志
Journal of Biomedical Engineering
;
(6): 691-695, 2019.
Article
in Chinese
| WPRIM
| ID: wpr-774153
ABSTRACT
Tumor cells have unique energy metabolism phenomena, namely high glucose absorption, aerobic glycolysis and high lactic acid production, which are characterized by down-regulation of related proteins involved in oxidative metabolism in tumor cells, and up-regulation of glucose transporters and monocarboxylate transporters. Studies have shown that drugs that target tumor cell glucose metabolism have the ability to selectively kill tumor cells, bringing new hope for tumor treatment. Tumor stem cells are considered to be the root cause of tumor recurrence, metastasis and poor prognosis, and their energy metabolism characteristics have not yet been agreed. Studies have shown that reversing the energy metabolism of tumor stem cells can increase their chemosensitivity. This article reviews recent studies on tumor and tumor stem cell glucose metabolism and the opportunities and challenges of tumor treatment through targeting glucose metabolism, which might provide new ideas and opportunities for clinical tumor therapy.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Neoplastic Stem Cells
/
Lactic Acid
/
Energy Metabolism
/
Glucose
/
Glycolysis
/
Metabolism
/
Neoplasms
Type of study:
Prognostic study
Limits:
Humans
Language:
Chinese
Journal:
Journal of Biomedical Engineering
Year:
2019
Type:
Article
Similar
MEDLINE
...
LILACS
LIS