Epi-Leptosphaerin: A New L-Isoascorbic Acid Derivative from Marine Sponges
Natural Product Sciences
;
: 293-296, 2015.
Article
in English
| WPRIM
| ID: wpr-7743
ABSTRACT
A new L-isoascorbic acid derivative epi-leptosphaerin (1) and two known compounds leptosphaerin (2), and verongamine (3) were isolated from sponges of the orders Verongida and Thorectidae. Compounds 1 and 2 are most likely of sponge-associated fungal origin. In the present study, isolated compounds were investigated for their inhibition of soluble epoxide hydrolase (sEH), which is considered a promising target for the management of pain, inflammation, and comorbidities associated with diabetes. Compound 3, verongamine, displayed weak inhibitory activity against sEH with an IC50 value 51.5 +/- 1.0 microM.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Porifera
/
Comorbidity
/
Inhibitory Concentration 50
/
Inflammation
Language:
English
Journal:
Natural Product Sciences
Year:
2015
Type:
Article
Similar
MEDLINE
...
LILACS
LIS