Expression and Clinical Significance of PD-L1 and MicroRNA-138-5p in Patients with Acute Myeloid Leukemia / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 373-378, 2019.
Article
in Chinese
| WPRIM
| ID: wpr-774307
ABSTRACT
OBJECTIVE@#To investigate the expression and clinical significance of PD-L1 and microRNA-138-5p in the peripheral blood mononuclear cells of patients with acute myeloid leukemia.@*METHODS@#The SYBR GreenⅠreal-time PCR was used to detect the expression levels of PD-L1 mRNA and miR-138 in 20 cases of primary AML, 9 cases of relapsed/refractory AML and 8 cases of complete remission. The samples of peripheral blood of 20 healthy peoples were used as controls.@*RESULTS@#The expression levels of PD-L1 in both the primary AML and the relapsed/refractory AML groups were significantly higher than those in the healthy control group (P0.05). and there was a negative correlation between PD-L1 mRNA and miR-138 in primary AML patients (P<0.05).@*CONCLUSION@#The expression of PD-L1 increases and the expression of miR-138 down-regulates in PBMNCs of AML patients, furthermore, both correlate each other.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Remission Induction
/
Leukocytes, Mononuclear
/
Leukemia, Myeloid, Acute
/
MicroRNAs
/
B7-H1 Antigen
/
Genetics
Limits:
Humans
Language:
Chinese
Journal:
Journal of Experimental Hematology
Year:
2019
Type:
Article
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