Deuteromethylactin B from a Freshwater-derived Streptomyces sp
Natural Product Sciences
;
: 261-267, 2015.
Article
in English
| WPRIM
| ID: wpr-7749
ABSTRACT
Compared to their terrestrial and marine counterparts, little is known about the capacity of freshwater-derived actinomycete bacteria to produce novel secondary metabolites. In the current study, we highlight the disparities that exist between cultivation-independent and -dependent analyses of actinomycete communities from four locations in Lake Michigan sediment. Furthermore, through phylogenetic analysis of strains isolated from these locations, we identified a Streptomyces sp., strain B025, as being distinct from other Streptomyces spp. isolated from sediment. Upon fermentation this strain produced a rare class of eight-membered lactone secondary metabolites, which have been for their antitumor properties. We used spectroscopic and chemical derivitization techniques to characterize octalactin B (1) in addition to its corresponding novel, unnatural degradation product (2).
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Streptomyces
/
Bacteria
/
Lakes
/
Michigan
/
Fermentation
/
Fresh Water
Country/Region as subject:
North America
Language:
English
Journal:
Natural Product Sciences
Year:
2015
Type:
Article
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