Multifunctional oral delivery systems for enhanced bioavailability of therapeutic peptides/proteins
Acta Pharmaceutica Sinica B
; (6): 902-922, 2019.
Article
in En
| WPRIM
| ID: wpr-774934
Responsible library:
WPRO
ABSTRACT
In last few years, therapeutic peptides/proteins are rapidly growing in drug market considering their higher efficiency and lower toxicity than chemical drugs. However, the administration of therapeutic peptides/proteins is mainly limited in parenteral approach. Oral therapy which was hampered by harsh gastrointestinal environment and poorly penetrating epithelial barriers often results in low bioavailability (less than 1%-2%). Therefore, delivery systems that are rationally designed to overcome these challenges in gastrointestinal tract and ameliorate the oral bioavailability of therapeutic peptides/proteins are seriously promising. In this review, we summarized various multifunctional delivery systems, including lipid-based particles, polysaccharide-based particles, inorganic particles, and synthetic multifunctional particles that achieved effective oral delivery of therapeutic peptides/proteins.
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Language:
En
Journal:
Acta Pharmaceutica Sinica B
Year:
2019
Type:
Article